The relationship between leukemia and TP53 gene codon Arg72Pro polymorphism: analysis in a multi-ethnic population
نویسندگان
چکیده
منابع مشابه
Association between TP53 gene Arg72Pro polymorphism and Wilms’ tumor risk in a Chinese population
Wilms' tumor is one of the most prevalent pediatric malignancies, ranking fourth in childhood cancer worldwide. TP53 is a critical tumor suppressor gene, which encodes a 53 kDa protein, p53. The p53 functions to protect against cancer by regulating cell cycle and apoptosis and maintaining DNA integrity. TP53 gene is highly polymorphic. Several TP53 gene polymorphisms have been considered to be ...
متن کاملThe Role of TP53 Gene Codon 72 Polymorphism in Leukemia
The purpose of this meta-analysis was aimed to evaluate the association of tumor protein p53 (TP53) gene codon 72 polymorphism with leukemia susceptibility. We searched PubMed to identify relevant studies, and 16 case-control studies from 14 published articles were identified as eligible studies, including 2062 leukemia patients and 5826 controls. After extracting data, odds ratio (OR) with the...
متن کاملAssociation between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies.
The relationship between the TP53 Arg72Pro polymorphism (rs1042522) and the risk of leukemia remains controversial. Consequently, we performed a meta-analysis to accurately evaluate the association between TP53 Arg72Pro polymorphism and leukemia risk. A comprehensive search was conducted to find all eligible studies of TP53 Arg72Pro polymorphism and leukemia risk. Fourteen case-control studies,...
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Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T polymorphism differs in various ethnical populations such as Asian, African, and Caucasians populations. A silent C3435T polymorphism in exon 26 of MDR1 has been reported to be associated with a decreased expression of P-gp in TT genotypes carriers compared with CC genotypes carriers. Materials and Methods: To evaluate ...
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ژورنال
عنوان ژورنال: Future Oncology
سال: 2020
ISSN: 1479-6694,1744-8301
DOI: 10.2217/fon-2019-0792